Regulation of the Mammalian Circadian Clock
at the University of Lausanne, Switzerland
For our new lab to be established in fall 2010 at the Center for Integrative Genomics (CIG) at the University of Lausanne (http://www.unil.ch/cig/), we are seeking 2 highly motivated PhD students with a background in molecular biology and/or biochemistry to join our team.
Circadian clocks can anticipate daytime and orchestrate temporal gene expression and associated physiological processes in a proactive manner. Typically 2-10% of an organ?s transcriptome are thus subject to circadian oscillations. According to current models, rhythmic transcription constitutes the mechanistic basis of these oscillations, both for the core clock genes and for the so-called output pathways which drive overt rhythms in physiology. However, circadian transcription is not sufficient to explain all the observations that have been made and suggest that important parts of the clock circuitry still remain to be defined.
Our lab will be studying circadian rhythms with a focus on the regulation by miRNAs and other post-transcriptional mechanisms. For our work, we will be using tissue culture cells and mice as model systems. PhD students will be exposed to a variety of molecular biology and RNA techniques, biochemistry, and work with cultured cells and mice. The CIG is a high-profile, friendly, modern institute beautifully located at Lake Geneva.
We invite applications from candidates with a degree in biochemistry, biology or related fields, with substantial experimental experience in molecular biology and biochemistry. Candidates must have excellent technical skills, an enthusiasm for using and developing new techniques, and good interpersonal skills to work within a young team of scientists.
Positions are available from November 2010.
Please send inquiries / applications via email to?david.gatfield@unige.ch
Current address: David Gatfield, Laboratory of Prof. Ueli Schibler, Department of Molecular Biology, Sciences III, 30, quai Ernest-Ansermet, CH-1211 Geneva, Switzerland, Tel: +41 22 3796185
